Manchester City seized the opportunity of Arsenal's 2-1 loss at Aston Villa earlier in the day to climb within two points of the leaders.
Arsenal missed the chance to go eight points clear at the top of the Premier League in a turgid 0-0 draw with champions Liverpool.
It took 10 Premier League games for the first cracks to appear in Manchester City's facade last season, but Pep Guardiola got a much earlier reminder of his side's fall from grace on Saturday in another defeat to Tottenham Hotspur.
James Milner sets a new Premier League record with his 654th appearance as Brighton beat Brentford 2-0, surpassing Gareth Barry's mark.
Arsenal missed a chance to tighten their grip on the Premier League title race with a 1-1 draw at 10-man Chelsea on Sunday.
Reach fifth round for first time in 10 years
Arsenal re-established their five-point lead at the top of the Premier League with a 2-0 home win against Brentford on Wednesday and for the second evening running the goals flowed as Aston Villa won 4-3 in a thriller at Brighton and Hove Albion.
West Bromwich Albion inflicted further misery on Manchester United, winning 2-1 at Old Trafford on Saturday to condemn the champions to their worst start to a Premier League season and leave them in the bottom half of the table after six games.
Sunderland defeated Newcastle United 2-1 with a late goal from Brian Brobbey, while Nottingham Forest secured a 3-0 victory over Tottenham Hotspur in Premier League action.
Premier League leaders Arsenal ended their mini-slump with an emphatic 4-0 victory at Leeds United on Saturday to move seven points clear despite Bukayo Saka being ruled out through injury just before kickoff.
Man City ease to 3-0 win over Liverpool as Guardiola celebrates 1,000th game in style
Arsenal moved nine points clear in the Premier League after beating Everton 2-0 as 16-year-old Max Dowman became the youngest scorer in league history, while Manchester City dropped points at West Ham.
Arsenal extends its lead in the Premier League, while Manchester United strengthens its top-four bid. Chelsea's Cole Palmer shines with a hat-trick, and West Ham earns a crucial win in their fight against relegation.
'Disorderly conduct, riots, injured police officers, and damage to infrastructure -- this is not a soccer game, this is a breach of order and serious violence.'
A round-up of Saturday's action in the Premier League.
A round-up of Tuesday's Champions League quarter-finals second leg between Barcelona and Dortmund, Aston Villa and Paris St Germain.
Lyon thump Maccabi Tel Aviv to go top, Forest keep on winning
A summary of Wednesday's Champions League Round of 16, Second Leg, matches.
Grealish made only seven league starts last season and was not included in City's recent Club World Cup squad.
Manchester City's spending of more than 180 million pounds ($223.58 million) was the second-biggest outlay ever worldwide by a club in the January transfer window.
Non-league Macclesfield produced perhaps the FA Cup's greatest upset on Saturday when they beat holders Crystal Palace 2-1 in a thirdround thriller, knocking Oliver Glasner's team out of the competition and sending the Moss Rose crowd into raptures.
Premier League leaders Arsenal needed two own goals, the second deep in stoppage time, to scrape a 2-1 home win over bottom club Wolverhampton Wanderers and open a five-point gap, while earlier on Saturday Mohamed Salah put aside a tumultuous week to help Liverpool beat Brighton and Hove Albion 2-0.
Manchester United's Benjamin Sesko scoring a stoppage-time equaliser to deny 18th-placed West Ham United a 1-0 win.
Beyond the handball incident, the Belgian champions were the better side on the night. Villa's World Cup-winning keeper Martinez was pressed into action early by Brugge, who had seven shots on target to the Premier League club's one, and made several key saves to keep his team in the game.
British Prime Minister Sir Keir Starmer, who is on a two-day visit to Mumbai, was joined by English football great Michael Owen.
Liverpool secured a dominant win over West Ham, while other Premier League matches saw Brentford edge Burnley in a seven-goal thriller and Everton secure a late victory against Newcastle.
According to the BCC, the prince has been a supporter of Aston Villa since his school days.
Chelsea's Enzo Fernandez scored a smash-and-grab goal deep in injury time to salvage a 1-1 draw with Manchester City on Sunday.
Manchester United have agreed a deal to sign goalkeeper Senne Lammens from Royal Antwerp on a five-year contract for 18.1 million pounds plus add-ons, according to British media reports.
Second-placed City would have reduced Arsenal's advantage to two points but instead were frustrated as their winning streak in all competitions was halted at eight.
Lewis-Skelly gets England call-up; Recalls Rashford, Henderson return.
Manchester City, Chelsea and Arsenal progressed to the FA Cup quarter-finals after victories over Newcastle United, Wrexham and Mansfield Town respectively on Saturday.
Substitute Gabriel Martinelli scored a late goal to help Arsenal hold Manchester City to a 1-1 draw in a blockbuster English Premier League fixture, in London, on Sunday.
Colombian super-sub Jhon Duran scored two late goals as Aston Villa salvaged a 3-3 home draw with Liverpool.
Rashford is not my player at the moment but every player that performs well on loan is good news for my club.
IMAGES from the Premier League matches played on Wednesday.
Bodo/Glimt secured an upset 3-1 victory over Serie A leaders Inter Milan in the first leg of their Champions League playoff on Wednesday.
Dinamo Zagreb and Celtic played out a lifeless 0-0 draw in the Champions League on Tuesday, with Celtic keeper Kasper Schmeichel producing the match's memorable moment with a late save.
IMAGES from the Premier League matches played on Sunday
Chelsea battled from two goals down to beat West Ham 3-2 in the Premier League on Saturday with a stoppage-time Enzo Fernandez winner.